Genomics of Rare Genetic Diseases Genomics for Understanding Rare Diseases India Alliance Network (GUaRDIAN) is a consortium of over 280 clinicians and researchers from over 60 medical and research centers making it one of the largest clinical genomics research networks in India.
Genomics for Public health in India (IndiGen) IndiGen programme aims to undertake whole genome sequencing of thousands of individuals representing diverse ethnic groups from India. The objective is to enable genetic epidemiology and develop public health technologies applications using population genome data.
Zebrafish Genome Biology
Non-Coding RNA Biology - We are interested in understanding Non-Coding RNA mediated regulation of vascular development and disease. We use a combination of zebrafish models and patient samples to decipher the underlying biological mechanism. Read more about the role of a novel vascular endothelial-associated lncRNA (VEAL2) in regulating endothelial permeability Sehgal et al., 2021, EMBO J
Genome of Zebrafish Wild-type Strain (ASWT) - The wild zebrafish (Danio rerio) genome sequencing initiative aims to capture the natural genetic variations in this popular vertebrate model organism. This opens opportunity to understand how natural genetic variations modulate phenotypic outcomes.
Other zebrafish genomic resources:
Genome Sequencing Initiatives (in collaboration with Dr. Vinod Scaria, CSIR-IGIB) For Potential Interns and Summer Students I have only limited opportunities for Interns/Summer students, usually 2 at a time. I would prefer someone who can spend 6 months or more. Please note that all prospective Interns and Summer Students need to write a short proposal (a paragraph would do) on an innovative idea they think could be performed during their internship. Interested candidates may please send the short proposal through email with the tag "Internship proposal" in the subject line. | Recent Publications
Sehgal P, Mathew S, Sivadas A, Ray A, Tanwar J, Vishwakarma S, Ranjan G, Shamsudheen KV, Bhoyar RC, Pateria A, Leonard E, Lalwani M, Vats A, Pappuru RR, Tyagi M, Jakati S, Sengupta S, B K B, Chakrabarti S, Kaur I, Motiani RK, Scaria V*, Sivasubbu S*. LncRNA VEAL2 regulates PRKCB2 to modulate endothelial permeability in diabetic retinopathy. EMBO J. 2021 Jun 28:e107134. doi: 10.15252/embj.2020107134.
Jain A, Bhoyar RC, Pandhare K, Mishra A, Sharma D, Imran M, Senthivel V, Divakar MK, Rophina M, Jolly B, Batra A, Sharma S, Siwach S, Jadhao AG, Palande NV, Jha GN, Ashrafi N, Mishra PK, A K V, Jain S, Dash D, Kumar NS, Vanlallawma A, Sarma RJ, Chhakchhuak L, Kalyanaraman S, Mahadevan R, Kandasamy S, B M P, Rajagopal RE, J ER, P ND, Bajaj A, Gupta V, Mathew S, Goswami S, Mangla M, Prakash S, Joshi K, S S, Gajjar D, Soraisham R, Yadav R, Devi YS, Gupta A, Mukerji M, Ramalingam S, Binukumar B K, Scaria V*, Sivasubbu S*. IndiGenomes: a comprehensive resource of genetic variants from over 1000 Indian genomes.Nucleic Acids Res. 2021 Jan 8;49(D1):D1225-D1232. doi: 10.1093/nar/gkaa923.
Bhoyar RC, Senthivel V, Jolly B, Imran M, Jain A, Divakar MK, Scaria V, Sivasubbu S*. An optimized, amplicon-based approach for sequencing of SARS-CoV-2 from patient samples using COVIDSeq assay on Illumina MiSeq sequencing platforms. STAR Protoc. 2021 Sep 17;2(3):100755. doi: 10.1016/j.xpro.2021.100755. [COVID19]
Mahadevan R, Bhoyar RC, Viswanathan N, Rajagopal RE, Essaki B, Suroliya V, Chelladurai R, Sankaralingam S, Shanmugam G, Vayanakkan S, Shamim U, Mathur A, Jain A, Imran M, Faruq M, Scaria V*, Sivasubbu S*, Kalyanaraman S*. Genomic analysis of patients in a South Indian community with autosomal dominant cortical tremor, myoclonus and epilepsy (ADCME) suggests a founder repeat expansion mutation in the SAMD12 gene. Brain Communications. 2021, fcaa214, https://doi.org/10.1093/braincomms/fcaa214
Jain A, Govindaraj GM, Edavazhippurath A, Faisal N, Bhoyar RC, Gupta V, Uppuluri R, Manakkad SP, Kashyap A, Kumar A, Divakar MK, Imran M, Sawant S, Dalvi A, Chakyar K, Madkaikar M, Raj R, Sivasubbu S, Scaria V. Whole genome sequencing identifies novel structural variant in a large Indian family affected with X-linked agammaglobulinemia. PLoS One. 2021 Jul 12;16(7):e0254407. doi: 10.1371/journal.pone.0254407.
Bhoyar RC, Jain A, Sehgal P, Divakar MK, Sharma D, Imran M, Jolly B, Ranjan G, Rophina M, Sharma S, Siwach S, Pandhare K, Sahoo S, Sahoo M, Nayak A, Mohanty JN, Das J, Bhandari S, Mathur SK, Kumar A, Sahlot R, Rojarani P, Lakshmi JV, Surekha A, Sekhar PC, Mahajan S, Masih S, Singh P, Kumar V, Jose B, Mahajan V, Gupta V, Gupta R, Arumugam P, Singh A, Nandy A, P V R, Jha RM, Kumari A, Gandotra S, Rao V, Faruq M, Kumar S, Reshma G B, Varma G N, Roy SS, Sengupta A, Chattopadhyay S, Singhal K, Pradhan S, Jha D, Naushin S, Wadhwa S, Tyagi N, Poojary M, Scaria V*, Sivasubbu S*. High throughput detection and genetic epidemiology of SARS-CoV-2 using COVIDSeq next-generation sequencing. PLoS One. 2021 Feb 17;16(2):e0247115. doi: 10.1371/journal.pone.0247115. [COVID19]
( * Indicates Corresponding Author)
|
