Whole Genome Sequencing Initiatives
Genomics for Precision Medicine in IndiaThe Genomics for Understanding Rare Disease, India Alliance Network (GUaRDIAN) is a unique initiative of the CSIR Institute of Genomics and Integrative Biology for pioneering the application of Genomics for Precision Medicine in India. GUaRDIAN is a large-scale collaborative network of clinicians from around India trying to integrate genomics in clinical practice, with a singular focus to elucidate the genetic structure of Rare Genetic Diseases in India.
Zebrafish Genome Biology @ CSIR-IGIB
For Potential Interns and Summer Students I have only limited opportunities for Interns/Summer students, usually 2 at a time. I would prefer someone who can spend 6 months or more. Please note that all prospective Interns and Summer Students need to write a short proposal (a paragraph would do) on an innovative idea they think could be performed during their internship. Interested candidates may please send the short proposal through email with the tag "Internship proposal" in the subject line.
| Recent Publications [Complete list of publications are available here] Vellarikkal SK, Jayarajan R, Verma A, Ravi R, Senthivel V, Kumar A,
Saini L, Gulati S, Lal M, Mathur A, Chhetri MK, Faruq M, Scaria V*,
Sivasubbu S*.
A founder mutation MLC1 c.736delA associated with
megalencephalic leukoencephalopathy with subcortical cysts-1in north
Indian kindred.
Clinical Genetics. 2018, (Accepted)
Sabharwal A, Sharma D, Vellarikkal SK, Jayarajan R, Verma A, Senthivel V, Scaria V*, Sivasubbu S*.
Organellar transcriptome sequencing reveals mitochondrial localization of nuclear encoded transcripts.
Mitochondrion. 2018 Feb 24. pii:S1567-7249(17)30106-X.
Kaushik K, Sivadas A, Vellarikkal SK, Verma A, Jayarajan R, Pandey S, Sethi T, Maiti, Scaria V*, Sivasubbu S*
RNA secondary structure profiling in zebrafish reveals unique regulatory features
.
BMC Genomics. 2018 Feb 15;19(1):147
Nahar S, Sehgal P, Azhar M, Rai M, Singh A, Sivasubbu S, Chakraborty D, Maiti S.
A G-quadruplex motif at the 3' end of sgRNAs improves CRISPR-Cas9 based genome editing efficiency.
Chem Commun (Camb). 2018 Mar 7;54(19):2377-2380.
Motiani RK, Tanwar J, Raja DA, Vashisht A, Khanna S, Sharma S, Srivastava S,Sivasubbu S, Natarajan VT, Gokhale RS.
STIM1 activation of adenylyl cyclase 6 connects Ca(2+) and cAMP signaling during melanogenesis.
EMBO J. 2018 Mar 1;37(5). pii: e97597.
Hariprakash JM, Vellarikkal SK, Keechilat P, Verma A, Jayarajan R,
Dixit V, Ravi R, Senthivel V, Kumar A, Sehgal P, Sonakar AK, Ambawat S,
Giri AK, Philip A, Sivadas A, Faruq M, Bharadwaj D, Sivasubbu S*, Scaria
V*.
Pharmacogenetic landscape of DPYD variants in south Asian populations by integration of genome-scale data.
Pharmacogenomics. 2018 Feb;19(3):227-241.
Biswas A, Das S, Kapoor M, Shamsudheen KV, Jayarajan R, Verma A, Seth S, Bhargava B, Scaria V, Sivasubbu S, Rao VR.
Familial hypertrophic cardiomyopathy - Identification of cause and risk stratification through exome sequencing.
Gene. 2018 Mar 20. pii: S0378-1119(18)30306-8
Mahajan R, Vellarikkal SK, Handa S, Verma A, Jayarajan R, Kumar A, De
D, Kaur J, Panigrahi I, VSl V, Sivasubbu S, Scaria V.
Utility of
whole exome sequencing in detecting novel compound heterozygous
mutations in COL7A1 among families with severe recessive Dystrophic
Epidermolysis Bullosa in India - implications on diagnosis, prognosis
and prenatal testing.
J Eur Acad Dermatol Venereol. 2018 Mar 6. doi: 10.1111/jdv.14909.
( * Indicates Corresponding Author) |
Personal Genomes to Personal Fish - By Pradha 2018
